Located in northeast Algeria, the coastal aquifer of the Plain of the El-Nil River constitutes a significant source of groundwater. It contains many municipal and private wells used for several purposes, including agriculture irrigation and drinking water. This paper describes a review of potential anthropogenic sources of groundwater contamination over the Plain of the El-Nil River territory. Different potential sources are identified, including 1) cultivated fields, 2) old private sanitation systems, 3) seawater intrusion, 4) dumpsite, and 5) the contaminated rivers crossing the study area. The multi-sources of contamination in the coastal aquifer of the Plain of the El-Nil River could affect large sectors of the aquifer. However, the existing documentation of groundwater contamination of the Plain of the El-Nil River is still limited. Hence, a hydrogeochemical study, including the analyses of major chemical elements and certain stable isotopes, is proposed as the principal outcome of this site-review paper. If undertaken, this proposed study is expected to provide more accurate information on groundwater contamination and, subsequently, could help decision-makers to prepare a practical plan for protecting the local water resources.