Nickel Is A Heavy Metal That May Affect The Function Of The Thyroid. The Present Study Was Undertaken To Assess The Protective Effects Of Selenium And Zinc Against Nickel-induced Thyrotoxicity In Preimplanted Wistar Albino Rats. Nickel Is Administered Alone (100 Mg/kg Body Weight) Subcutaneously Or In Combination With Selenium (0.3 Mg/kg Body Weight) Either With Zinc (20 Mg/kg Body Weight) Or Combined With Both Selenium And Zinc. All Groups Of Rats Were Injected On Day 3 Of Gestation In The Pre-implantation Period. Exposure Of Rats To Nickel Caused A Significant Decrease In Maternal Body Weight On Days 6 And 20 Of Gestation And An Increase In Absolute And Relative Thyroid Weight Compared To The Controls. Nickel Treatment Was Also Led In Decreased Plasma Triiodothyronine, Thyroxine With A Concomitant Significant Increase In Thyroid-stimulating Hormone Levels When Compared To Control. These Changes Were Confirmed By Histological Damages. However, Co-administration Of Selenium And/or Zinc To Nickel-treated Rats Restored The Hormonal And Histological Aspects. Our Findings Suggested That Selenium And Zinc Ameliorated Nickel Induced Thyroid Damage.

: The aim of this study was to investigate that nickel chloride (NiCl2) induced reproductive toxicity in pre- implanted Wistar Rats and examined the possible protective effect of zinc chloride and selenium on plasma concentration of the hormones of 17 b etradiol (E2) and progesterone (prog); on the reproductive organ’s histology and on development. Experimental results showed the subcutaneous (s.c) administration of Nicl2 to Wistar albino Rats induced a decrease in plasma concentration of E2 and prog in addition, disturbance in development parameters and structural damages to the histology of the reproductive organs. Conversely, Se and ZnCl2 dues to the antioxidants property, regulate the secretion of E2 and Prog hormones, prevent alterations in the reproductive organs and in development in preimplanted rates receiving NiCl2.