Lecithin-cholesterol acyltransferase (LCAT) deficiency is an autosomal recessive disorder that can reveal two different diseases: a very interesting nephrological picture of complete enzyme deficiency characterized by the association of dyslipidemia, corneal opacities, anemia, and progressive nephropathy; and a partial form (fish-eye disease) with dyslipidemia and progressive corneal opacities only. We report herein the case of a 35-year-old man who presented hypertension, renal symptomatology of rapidly progressive glomerulonephritis associates: nephrotic proteinuria, severe renal failure, in combination with annular corneal opacities, anemia, and dyslipidemia. The diagnosis of familial LCAT deficiency was confirmed by clinical examination, characteristic dyslipidemia, undetectable LCAT levels in plasma, and positive family history.

SARS-CoV-2 vaccines are being administered worldwide. Most side effects are mild and self-limiting with few reported cases of severe reactions. We report a case of leukocytoclastic vasculitis with acute kidney failure following aninactivated SARS-CoV-2 vaccine, unique for its dramatic visual presentation and its rapid response to treatment. This is the case of a 58years-old man presenting with fever, arthralgias and vascular purpura on his limbs associated with acute kidney failure requiring hemodialysis nine days after anti-COVID-19 vaccination. Skin biopsy revealed a leukocytoclastic vasculitis and a renal biopsy showed an acute tubulointerstitial nephritis. The vascular purpura resolved 7days after initiating treatment with prednisone but the patient remains in chronic renal failure. The analysis and investigation of the complications and adverse events induced by anti-COVID-19 vaccines could increase our understanding of the underlying pathogenesis.

Biologically active compounds isolated from medicinal herbs have been the center of interest for researchers to investigate their possible effects and mechanisms through which they exert their action. In the current study, we investigated the antiproliferative effect and the mechanism of action of deoxypodophyllotoxin, a semi-synthetic compound derived from the extract of a Chinese herbal medicine, Dysosma versipellis (Hance) M. Cheng ex Ying (Berberidaceae). The study was conducted on MCF-7 and MDA-MB-231 breast cancer cell lines. The antiproliferative effect of deoxypodophyllotoxin was assessed by the Cell Counting Kit-8 assay. Flow cytometry, Annexin V/PI, mitochondrial membrane potential, caspase inhibition assays, and western blot analysis were performed to detect, explore, and assess the antiproliferative effect of deoxypodophyllotoxin. Our data revealed that, deoxypodophylloto…