@proceedings {7662,
	title = {The Mitigative Effect Of Selenium Against Hexavalent Chromium Induced- Toxicity In Liver Of Pregnant Wistar Rats},
	journal = {1st International Seminar on Pollution, Health, Environment and Bio-monitoring SIPSEB{\textquoteright}21 DECEMBER 27-28,},
	year = {2021},
	address = {skikda, Algeria},
	author = {Anfal Fedala and Ounassa Adjroud and Salwa Abid-Essefi and Rim Timoumi}
}
@proceedings {7661,
	title = {L\&rsquo;{\'e}valuation de la perturbation thyro{\"\i}dienne induite par le dichromate de potassium chez la rate gestante ALBINOS WISTAR},
	journal = {1er S{\'e}minaire International PERTURBATEURS ENDOCRINIENS ENVIRONNEMENT \& REPRODUCTION (PEER 2021) tenu du 07 au 08 juillet},
	year = {2021},
	address = {Blida, Alg{\'e}rie},
	author = {Anfal Fedala and Ounassa Adjroud}
}
@article {7653,
	title = {CHROMIUM TOXICITY ON THE ELECTROLYTE BALANCE AND ADRENAL HISTOLOGY IN WISTAR MALE RATS},
	journal = {~Nutr.Sant{\'e}},
	volume = {10},
	number = {1},
	year = {2021},
	author = {Sengouga, Djouhaina and Ounassa Adjroud and Imane Salah and Anfal Fedala}
}
@article {article,
	title = {Protection of Steel Against Corrosion in Acid Medium Using Dihydropyrimidinone Derivatives: Experimental and DFT Study},
	journal = {Iranian Journal of Science and Technology, Transactions A: Science},
	volume = {45},
	year = {2021},
	month = {05},
	abstract = {
	Two dihydropyrimidinone derivatives (DHPM) were synthesized via the multi-component reaction, the yield of the synthesis reached 90\%, and their structures were proved by IR,\&nbsp;1H and\&nbsp;13C NMR spectroscopy. The identified molecules were used for studying the corrosion inhibition of XC48 carbon steel in 0.5\&nbsp;mol\&nbsp;L-1\&nbsp;H2SO4\&nbsp;solution. The inhibitory potentials of these compounds were determined by electrochemical methods exploiting the potentiodynamic polarization curves (Tafel method) and electrochemical impedance spectroscopy. Surface phenomena have been illustrated by atomic force microscopy. The results obtained show that the synthesized molecules are effective inhibitors, whose efficiency corrosion inhibition depends on the architecture of their structure, and it is proportional to the concentrations; it exceeds 94\% for one of these inhibitors. The adsorption of these compounds on the metal surface approached the Langmuir{\textquoteright}s adsorption isotherm. Furthermore, the electronic properties obtained using density function theory are in a good consensus with the experimental efficiencies of inhibition. The molecular dynamics simulations have allowed also simulating the interactions between the inhibitors and the metallic surface.

},
	doi = {10.1007/s40995-021-01140-1},
	url = {https://link.springer.com/article/10.1007/s40995-021-01140-1},
	author = {Mammeri, Samia and Chafai, Nadjib and Hassina Harkat and Rachida, Kerkour and Chafaa, Salah}
}
@article {article,
	title = {Chemical composition, in vitro antioxidant and antibacterial activities of Centaurea resupinata subsp. dufourii (dost{\'a}l) greuter},
	journal = {Natural Product Research},
	volume = {35},
	number = {22},
	year = {2021},
	month = {01},
	pages = {1-5},
	abstract = {
	The current study focuses on the chemical composition, and evaluation of antioxidant and antibacterial activity of the aerial parts of\&nbsp;Centaurea resupinata\&nbsp;subsp.\&nbsp;dufourii. Using different chromatographic methods nine compounds 1{\textendash}9 were isolated. The structural identification of isolated compounds was achieved using several spectroscopic methods NMR techniques (1H NMR,\&nbsp;13C NMR, COSY, HSQC, HMBC) and mass spectroscopy (ESI-MS) and by comparison with literature data. The structures of these compounds were identified as nicotiflorin (1), apigetrin (2), chrysoeriol (3), apigenin (4), chrysin (5), daucosterol (6), β-sitosterol (7), taraxastrerol (8) and lupeol (9). The antibacterial and antioxidant activities of ethyl acetate and\&nbsp;n-butanol extracts have been evaluated. The antioxidant activity was assessed in\&nbsp;vitro using DPPH radical scavenging method, which showed that ethyl acetate extract possessed an interesting antioxidant potential (IC50 = 36.263 {\textpm} 0.005 μg/mL).



	\&nbsp;



	

},
	doi = {10.1080/14786419.2020.1715397},
	url = {https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1715397?journalCode=gnpl20},
	author = {Bouzghaia, Badra and Ben Moussa, Mohammed and Goudjil, Rima and Hassina Harkat and Patrick Pale}
}
@article {6264,
	title = {ZINC ALLEVIATES POTASSIUM DICHROMATE-INDUCED HEPATOTOXICITY IN PREGNANT WISTAR RATS},
	journal = {Malaysian Journal Of  Biochemistry \& Molecular Biology },
	volume = {2},
	year = {2021},
	pages = {10-16 },
	abstract = {
	The present study aimed to investigate the potential protective effects of zinc (Zn) against hexavalent chromium-induced hepatotoxicity in pregnant Wistar rats. Female rats were treated subcutaneously (s.c) on the 3 rd day of pregnancy, with NaCl 0.9 \% and served as control, K$_{2}$Cr$_{2}$O7 (10 mg/kg bw) alone, or K$_{2}$Cr$_{2}$O7 in association with ZnCl2 (20 mg/kg bw). Hepatic biochemical parameters, oxidative stress biomarkers and DNA damage were monitored. Results revealed that K$_{2}$Cr$_{2}$O7 disturbed plasma ALT, AST, ALP and GGT, induced hepatic oxidative stress and DNA fragmentation. The co-treatment with Zn has alleviated K2Cr2O7-induced hepatotoxicity by exhibiting antioxidant and genoprotective effects in pregnant Wistar rats.

},
	author = {Anfal Fedala and ADJROUD OUNASSA and Asma Saouli and Salah Imane}
}
@article {6261,
	title = {Protective effects of selenium and zinc against potassium dichromate\&ndash;induced thyroid disruption, oxidative stress, and DNA damage in pregnant Wistar rats},
	journal = {Environmental Science and Pollution Research},
	volume = {28},
	year = {2021},
	pages = {22563{\textendash}22576},
	abstract = {
	Hexavalent chromium (CrVI) is an environmental pollutant and an endocrine-disrupting metal. Se and Zn are essential trace elements, known to play a crucial role in thyroid homeostasis. However, there is a lack of data reporting thyrotoxicity during gestation. In this study, we investigated the protective effects of selenium and zinc against potassium dichromate{\textendash}induced thyrotoxicity in pregnant Wistar rats. Thirty pregnant Wistar rats were divided into control and four treated groups receiving subcutaneously (s.c) on the 3rd day of pregnancy, K2Cr2O7\&nbsp;(10 mg/kg, s.c) alone, or in association with Se (0.3 mg/kg, s.c), ZnCl2\&nbsp;(20 mg/kg, s.c), or both of them simultaneously. The hormonal profile, oxidative stress biomarkers, DNA damage, and histological modifications were evaluated. Our main findings showed that K2Cr2O7\&nbsp;promoted hypothyroidism, oxidative stress, genotoxicity, and histological alterations in the thyroid gland. The co-treatment with Se or ZnCl2\&nbsp;has mitigated K2Cr2O7-induced thyrotoxicity in pregnant Wistar rats by exhibiting antioxidant and genoprotective effects. However, the combined co-treatment of both of them was less thyroprotective, and therefore, further investigations on the synergetic interaction of Se and Zn against CrVI toxicity using different doses and exposure routes are required.

},
	author = {Anfal Fedala and Ounassa Adjroud and Salwa Abid-Essefi and Rim Timoumi}
}
@article {6233,
	title = {Protective Effects of Selenium and Zinc Against Nickel Chloride\&ndash;Induced Hormonal Changes and Oxidative Damage in Thyroid of Pregnant Rats},
	journal = {Biological Trace Element Research },
	volume = {155},
	year = {2021},
	abstract = {
	Nickel chloride (NiCl2) is a heavy metal that may affect the function of the thyroid. Selenium (Se) and zinc (Zn) are essential trace elements involved in thyroid hormone metabolism. However, little is reported about thyrotoxicity during gestation. The current study aimed to investigate the protective effects of selenium and zinc against NiCl2-induced thyrotoxicity in pregnant Wistar rats. Female rats were treated subcutaneously (s.c.) on the 3rd day of pregnancy, with NaCl 0.9\% and served as control, NiCl2\&nbsp;(100\&nbsp;mg/kg body weight (BW)) alone, or in association with Se (0.3\&nbsp;mg/kg, s.c.), ZnCl2\&nbsp;(20\&nbsp;mg/kg, s.c.), or both of them simultaneously. Oxidative stress parameters, thyroid biomarkers, and histopathological examination were evaluated. Results showed that NiCl2\&nbsp;exposure caused a significant decrease in maternal body weight and an increase in absolute and relative thyroid weight compared to the controls. NiCl2\&nbsp;administration also led to decreased plasma triiodothyronine (T3) and thyroxine (T4) with a concomitant significant increase in thyroid-stimulating hormone (TSH) levels when compared to that of control. In addition, an overall pro-oxidant effect was associated with a decrease in the reduced glutathione (GSH) and nonprotein thiol (NPSH) contents and the enzymatic activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD), and an increase in malondialdehyde (MDA). These biochemical disturbances were confirmed by histological changes. However, the co-treatment of Se and/or ZnCl2\&nbsp;attenuates NiCl2-induced changes. Our findings suggested that Se and ZnCl2\&nbsp;ameliorated NiCl2-induced thyrotoxicity in pregnant Wistar rats by exhibiting antioxidant effects.

},
	author = {Imane Salah and Ounassa Adjroud and Awatef Elwej}
}
