@article {7652,
	title = {Protective Effects of Selenium and Zinc Against Nickel Chloride-Induced Hormonal Changes and Oxidative Damage in Thyroid of Pregnant Rats},
	journal = {Biological Trace Element Research},
	volume = {200},
	number = {5},
	year = {2022},
	pages = {2183-2194},
	abstract = {
	Nickel chloride (NiCl2) is a heavy metal that may affect the function of the thyroid. Selenium (Se) and zinc (Zn) are essential trace elements involved in thyroid hormone metabolism. However, little is reported about thyrotoxicity during gestation. The current study aimed to investigate the protective effects of selenium and zinc against NiCl2-induced thyrotoxicity in pregnant Wistar rats. Female rats were treated subcutaneously (s.c.) on the 3rd day of pregnancy, with NaCl 0.9\% and served as control, NiCl2\&nbsp;(100 mg/kg body weight (BW)) alone, or in association with Se (0.3 mg/kg, s.c.), ZnCl2\&nbsp;(20 mg/kg, s.c.), or both of them simultaneously. Oxidative stress parameters, thyroid biomarkers, and histopathological examination were evaluated. Results showed that NiCl2\&nbsp;exposure caused a significant decrease in maternal body weight and an increase in absolute and relative thyroid weight compared to the controls. NiCl2\&nbsp;administration also led to decreased plasma triiodothyronine (T3) and thyroxine (T4) with a concomitant significant increase in thyroid-stimulating hormone (TSH) levels when compared to that of control. In addition, an overall pro-oxidant effect was associated with a decrease in the reduced glutathione (GSH) and nonprotein thiol (NPSH) contents and the enzymatic activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD), and an increase in malondialdehyde (MDA). These biochemical disturbances were confirmed by histological changes. However, the co-treatment of Se and/or ZnCl2\&nbsp;attenuates NiCl2-induced changes. Our findings suggested that Se and ZnCl2\&nbsp;ameliorated NiCl2-induced thyrotoxicity in pregnant Wistar rats by exhibiting antioxidant effects.

},
	url = {https://pubmed.ncbi.nlm.nih.gov/34247319/},
	author = {Imane Salah and Ounassa Adjroud and Awatef Elwej}
}
@article {7651,
	title = {Nephroprotective Efficacy of Selenium and Zinc Against Potassium Dichromate-Induced Renal Toxicity in Pregnant Wistar Albino Rats},
	journal = {Biological Trace Element Research},
	volume = {200},
	number = {11},
	year = {2022},
	pages = {4782-4794},
	abstract = {
	Hexavalent chromium (CrVI) compounds are potent toxicants commonly used in numerous industries. Thus, potential toxic effects and health hazards are of high relevance. Selenium (Se) and zinc (Zn) are known for their antioxidant and chemoprotective properties. However, little is known about their protective effects against CrVI-induced renal damage during pregnancy. In this context, the present study aimed to investigate the protective efficacy of these two essential elements against potassium dichromate-induced nephrotoxicity in pregnant Wistar Albino rats. Female rats were divided into control and four treated groups of six each receiving subcutaneously on the 3rd day of pregnancy, K2Cr2O7\&nbsp;(10 mg/kg, s.c. single dose) alone, or in association with Se (0.3 mg/kg, s.c. single dose), ZnCl2\&nbsp;(20 mg/kg, s.c. single dose) or both of them simultaneously. The nephrotoxic effects were monitored by the evaluation of plasma renal parameters, oxidative stress biomarkers, DNA damage, and renal Cr content. The obtained results showed that K2Cr2O7\&nbsp;disturbed renal biochemical markers, induced oxidative stress and DNA fragmentation in kidney tissues, and altered renal histoarchitecture. The co-administration of Se and/or ZnCl2\&nbsp;has exhibited pronounced chelative, antioxidant, and genoprotective effects against K2Cr2O7-induced renal damage and attenuated partially the histopathological alterations. These results suggest that Se and Zn can be used as efficient nephroprotective agents against K2Cr2O7-induced toxicity in pregnant Wistar Albino rats.

},
	url = {https://pubmed.ncbi.nlm.nih.gov/35066750/},
	author = {Anfal Fedala and Ounassa Adjroud and Omar Bennoune and Salwa Abid-Essefi and Foughalia, Abdelhamid and Rim Timoumi}
}
@proceedings {7662,
	title = {The Mitigative Effect Of Selenium Against Hexavalent Chromium Induced- Toxicity In Liver Of Pregnant Wistar Rats},
	journal = {1st International Seminar on Pollution, Health, Environment and Bio-monitoring SIPSEB{\textquoteright}21 DECEMBER 27-28,},
	year = {2021},
	address = {skikda, Algeria},
	author = {Anfal Fedala and Ounassa Adjroud and Salwa Abid-Essefi and Rim Timoumi}
}
@proceedings {7661,
	title = {L\&rsquo;{\'e}valuation de la perturbation thyro{\"\i}dienne induite par le dichromate de potassium chez la rate gestante ALBINOS WISTAR},
	journal = {1er S{\'e}minaire International PERTURBATEURS ENDOCRINIENS ENVIRONNEMENT \& REPRODUCTION (PEER 2021) tenu du 07 au 08 juillet},
	year = {2021},
	address = {Blida, Alg{\'e}rie},
	author = {Anfal Fedala and Ounassa Adjroud}
}
@article {7653,
	title = {CHROMIUM TOXICITY ON THE ELECTROLYTE BALANCE AND ADRENAL HISTOLOGY IN WISTAR MALE RATS},
	journal = {~Nutr.Sant{\'e}},
	volume = {10},
	number = {1},
	year = {2021},
	author = {Sengouga, Djouhaina and Ounassa Adjroud and Imane Salah and Anfal Fedala}
}
@article {6261,
	title = {Protective effects of selenium and zinc against potassium dichromate\&ndash;induced thyroid disruption, oxidative stress, and DNA damage in pregnant Wistar rats},
	journal = {Environmental Science and Pollution Research},
	volume = {28},
	year = {2021},
	pages = {22563{\textendash}22576},
	abstract = {
	Hexavalent chromium (CrVI) is an environmental pollutant and an endocrine-disrupting metal. Se and Zn are essential trace elements, known to play a crucial role in thyroid homeostasis. However, there is a lack of data reporting thyrotoxicity during gestation. In this study, we investigated the protective effects of selenium and zinc against potassium dichromate{\textendash}induced thyrotoxicity in pregnant Wistar rats. Thirty pregnant Wistar rats were divided into control and four treated groups receiving subcutaneously (s.c) on the 3rd day of pregnancy, K2Cr2O7\&nbsp;(10 mg/kg, s.c) alone, or in association with Se (0.3 mg/kg, s.c), ZnCl2\&nbsp;(20 mg/kg, s.c), or both of them simultaneously. The hormonal profile, oxidative stress biomarkers, DNA damage, and histological modifications were evaluated. Our main findings showed that K2Cr2O7\&nbsp;promoted hypothyroidism, oxidative stress, genotoxicity, and histological alterations in the thyroid gland. The co-treatment with Se or ZnCl2\&nbsp;has mitigated K2Cr2O7-induced thyrotoxicity in pregnant Wistar rats by exhibiting antioxidant and genoprotective effects. However, the combined co-treatment of both of them was less thyroprotective, and therefore, further investigations on the synergetic interaction of Se and Zn against CrVI toxicity using different doses and exposure routes are required.

},
	author = {Anfal Fedala and Ounassa Adjroud and Salwa Abid-Essefi and Rim Timoumi}
}
@article {6233,
	title = {Protective Effects of Selenium and Zinc Against Nickel Chloride\&ndash;Induced Hormonal Changes and Oxidative Damage in Thyroid of Pregnant Rats},
	journal = {Biological Trace Element Research },
	volume = {155},
	year = {2021},
	abstract = {
	Nickel chloride (NiCl2) is a heavy metal that may affect the function of the thyroid. Selenium (Se) and zinc (Zn) are essential trace elements involved in thyroid hormone metabolism. However, little is reported about thyrotoxicity during gestation. The current study aimed to investigate the protective effects of selenium and zinc against NiCl2-induced thyrotoxicity in pregnant Wistar rats. Female rats were treated subcutaneously (s.c.) on the 3rd day of pregnancy, with NaCl 0.9\% and served as control, NiCl2\&nbsp;(100\&nbsp;mg/kg body weight (BW)) alone, or in association with Se (0.3\&nbsp;mg/kg, s.c.), ZnCl2\&nbsp;(20\&nbsp;mg/kg, s.c.), or both of them simultaneously. Oxidative stress parameters, thyroid biomarkers, and histopathological examination were evaluated. Results showed that NiCl2\&nbsp;exposure caused a significant decrease in maternal body weight and an increase in absolute and relative thyroid weight compared to the controls. NiCl2\&nbsp;administration also led to decreased plasma triiodothyronine (T3) and thyroxine (T4) with a concomitant significant increase in thyroid-stimulating hormone (TSH) levels when compared to that of control. In addition, an overall pro-oxidant effect was associated with a decrease in the reduced glutathione (GSH) and nonprotein thiol (NPSH) contents and the enzymatic activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD), and an increase in malondialdehyde (MDA). These biochemical disturbances were confirmed by histological changes. However, the co-treatment of Se and/or ZnCl2\&nbsp;attenuates NiCl2-induced changes. Our findings suggested that Se and ZnCl2\&nbsp;ameliorated NiCl2-induced thyrotoxicity in pregnant Wistar rats by exhibiting antioxidant effects.

},
	author = {Imane Salah and Ounassa Adjroud and Awatef Elwej}
}
@proceedings {7684,
	title = {The antagonistic effect of the association of zinc and selenium on chromium induced toxicity in rat\&rsquo;s Testis},
	journal = {1ere Journ{\'e}e Scientifique sur la Biologie des plantes M{\'e}dicinales  22 Janvier},
	year = {2020},
	address = {T{\'e}bessa, Alg{\'e}rie},
	author = {Sengouga, Djouhaina and Ounassa Adjroud and Anfal Fedala and Imane Salah}
}
@proceedings {7683,
	title = {Hexavalent chromium - induced nephrotoxicity and its zinc and selenium antagonism in Wistar rat},
	journal = {Association nationale eco-conception, analyse de vie et d{\'e}veloppement durable affili{\'e} au r{\'e}seau des clubs UNESCO en Alg{\'e}rie. F{\'e}vrier},
	year = {2020},
	author = {Sengouga, Djouhaina and Ounassa Adjroud and Anfal Fedala and Imane Salah}
}
@article {7654,
	title = {Potential Protective Effects of Selenium and Zinc against Thyroid Toxicity Induced by Nickel in Preimplanted Wistar Albino Rats},
	journal = {Toxicology International},
	volume = {26},
	number = {1},
	year = {2020},
	pages = {54{\textendash}63},
	abstract = {
	Nickel Is A Heavy Metal That May Affect The Function Of The Thyroid. The Present Study Was Undertaken To Assess The Protective Effects Of Selenium And Zinc Against Nickel-induced Thyrotoxicity In Preimplanted Wistar Albino Rats. Nickel Is Administered Alone (100 Mg/kg Body Weight) Subcutaneously Or In Combination With Selenium (0.3 Mg/kg Body Weight) Either With Zinc (20 Mg/kg Body Weight) Or Combined With Both Selenium And Zinc. All Groups Of Rats Were Injected On Day 3 Of Gestation In The Pre-implantation Period. Exposure Of Rats To Nickel Caused A Significant Decrease In Maternal Body Weight On Days 6 And 20 Of Gestation And An Increase In Absolute And Relative Thyroid Weight Compared To The Controls. Nickel Treatment Was Also Led In Decreased Plasma Triiodothyronine, Thyroxine With A Concomitant Significant Increase In Thyroid-stimulating Hormone Levels When Compared To Control. These Changes Were Confirmed By Histological Damages. However, Co-administration Of Selenium And/or Zinc To Nickel-treated Rats Restored The Hormonal And Histological Aspects. Our Findings Suggested That Selenium And Zinc Ameliorated Nickel Induced Thyroid Damage.

},
	url = {https://www.informaticsjournals.com/index.php/toxi/article/view/24438},
	author = {Imane Salah and Ounassa Adjroud and Anfal Fedala and Asma Saouli}
}
@article {6265,
	title = {PROTECTIVE EFFECTS OF SELENIUM AND ZINC ON NICKEL CHLORIDE INDUCED REPRODUCTIVE TOXICITY IN WISTAR ALBINOS PREIMPLANTED RATS},
	journal = {Studia Universitatis Vasile Goldis Seria Stiintele Vietii (Life Sciences ) },
	volume = {30},
	number = {3},
	year = {2020},
	pages = {126 - 135},
	abstract = {
	: The aim of this study was to investigate that nickel chloride (NiCl2) induced reproductive toxicity in pre- implanted Wistar Rats and examined the possible protective effect of zinc chloride and selenium on plasma concentration of the hormones of 17 b etradiol (E2) and progesterone (prog); on the reproductive organ{\textquoteright}s histology and on development. Experimental results showed the subcutaneous (s.c) administration of Nicl2 to Wistar albino Rats induced a decrease in plasma concentration of E2 and prog in addition, disturbance in development parameters and structural damages to the histology of the reproductive organs. Conversely, Se and ZnCl2 dues to the antioxidants property, regulate the secretion of E2 and Prog hormones, prevent alterations in the reproductive organs and in development in preimplanted rates receiving NiCl2.

},
	author = {Ismahene BOULILA and Ounassa Adjroud}
}
@proceedings {7685,
	title = {Protective effect of zinc and selenium against chromium hematotoxicity and water consumption in the rats},
	journal = {1ere Journ{\'e}e de Biotoicologie et Bioactivit{\'e}, 27 Nov},
	year = {2019},
	address = {Oran, Algeria},
	author = {Sengouga, Djouhaina and Ounassa Adjroud and Imane Salah and Anfal Fedala}
}
@proceedings {63568,
	title = {Evaluation de l\&rsquo;hepatotoxicite induite par le dichromate de potassium chez les rates gestantes de la souche albinos wistar},
	year = {2019},
	month = {2019},
	address = {Universit{\'e} Mostefa BEN BOULAID- Batna 2, Alg{\'e}rie},
	author = {FEDALA ANFAL and Ounassa Adjroud and Asma Saouli}
}
@proceedings {7663,
	title = {Protective effect of zinc and selenium against chromium hematotoxicity and water consumption in the rats},
	journal = {1ere Journ{\'e}e de Biotoicologie et Bioactivit{\'e}, 27 nov,},
	year = {2019},
	address = {Oran, Algeria},
	author = {Sengouga, Djouhaina and Ounassa Adjroud and Imane Salah and Anfal Fedala}
}
@proceedings {6286,
	title = {Effet pretecteur de la supplementation en s{\'e}l{\'e}nium contre la n{\'e}phrotoxicit{\'e} induite par le chlorure de nickel chez la rate gestante},
	journal = { Deuxi{\`e}me Journ{\'e}e Aurassienne de Biologie Mol{\'e}culaire ~},
	year = {2019},
	address = {Batna, Alg{\'e}rie},
	author = {Imane Salah and Ounassa Adjroud}
}
@proceedings {6278,
	title = {Hematotoxicite induite par le nickel chez la rate gestante de souche wistar},
	journal = {Premier Colloque International sur la Lutte Biologique et Int{\'e}gr{\'e}e en Algerie {\guillemotleft} CILBIA1 {\guillemotright} .  Du 04-06 f{\'e}vrier },
	year = {2019},
	address = {  Universit{\'e} Mostefa BEN BOULAID- Batna 2, Alg{\'e}rie},
	author = {Ismahene BOULILA and Ounassa Adjroud}
}
@proceedings {6277,
	title = {Etude de la toxicit{\'e} r{\'e}nale du chlorure de nickel chez la rate gestante Albinos Wistar},
	journal = { Premier Colloque International sur la Lutte Biologique et Int{\'e}gr{\'e}e en Algerie {\guillemotleft} CILBIA1 {\guillemotright} .  Du 04-06 f{\'e}vrier },
	year = {2019},
	address = { Universit{\'e} Mostefa BEN BOULAID- Batna 2, Alg{\'e}rie},
	author = {Imane Salah and Ounassa Adjroud}
}
@proceedings {6275,
	title = {Effets du dichromate de patassium sur la ligne lymphocytaire et leucocytaire chez la rate gestante Albinos Wistar},
	journal = { Premier Colloque International sur la Lutte Biologique et Int{\'e}gr{\'e}e en Algerie {\guillemotleft} CILBIA1 {\guillemotright} .  Du 04-06 f{\'e}vrier },
	year = {2019},
	address = {Universit{\'e} Mostefa BEN BOULAID- Batna 2},
	author = {Asma Saouli and Ounassa Adjroud and Asma Saouli}
}
@proceedings {6285,
	title = {Les effets du chrome hexavalent sur la ligne thrombocytaire chez la rate gestante Albinos Wistar},
	journal = {S{\'e}minaire National Biologie Environnement et Sant{\'e} {\guillemotleft} SNBES 2018 {\guillemotright}. 08-09 Octobre },
	year = {2018},
	address = {Universit{\'e} 20 Aout 1955 Skikda, },
	author = {Asma Saouli and Ounassa Adjroud and Anfal Fedala}
}
@proceedings {6283,
	title = {L\&rsquo;effet n{\'e}phrotoxique du chrome hexavalent chez la rate gestante de la souche Albinos wistar},
	journal = {Le s{\'e}minaire national(BiEnSa{\textquoteright}2018).28 et 29 November},
	year = {2018},
	address = {Jijel.Alg{\'e}rie},
	author = {Anfal Fedala and Ounassa Adjroud and Asma Saouli}
}
@proceedings {6274,
	title = {Contribution {\`a} la recherche des effets immunotoxiques du chrome hexavalent chez la rate gestante de la souche Albinos Wistar.},
	journal = {Le Premier S{\'e}minaire International sur L{\textquoteright}Agroalimentaire {\guillemotleft} SIA 2018 {\guillemotright}},
	year = {2018},
	address = {Universit{\'e} 8 Mai 1945 Guelma},
	author = {Anfal Fedala and Ounassa Adjroud and Asma Saouli}
}
@proceedings {7666,
	title = {Effets de la forte dose de chlorure de nickel seul administr{\'e}e par voie sous cutan{\'e}e sur les param{\`e}tres h{\'e}matologique et l\&rsquo;histologie des testicules chez les rats males de la soucheWistar},
	journal = {6{\`e}me journ{\'e}es de l{\textquoteright}ATT : processus toxiques-bioactivit{\'e}-biosurvaillance.21,23/01/2017},
	year = {2017},
	address = {Tabarka.Tunisie},
	author = {Boulila, Ismahan and Ounassa Adjroud}
}
@proceedings {64554,
	title = {L\&rsquo;effet du nickel administr{\'e} par voie sous cutan{\'e}e et son {\'e}ventuelle interaction avec le s{\'e}l{\'e}nium et le zinc sur la leucopo{\"\i}{\`e}se et l\&rsquo;histologie h{\'e}patique},
	journal = {6{\`e}mes Journ{\'e}es Scientifiques de l{\textquoteright}Association Tunisienne de Toxicologie(ATT). 21 -23 Janvier},
	year = {2017},
	month = {2017},
	address = {TABERKA ,TUNISIE},
	author = {Anfal Fedala and Ounassa Adjroud}
}
@proceedings {6282,
	title = {Effets de l\&rsquo;administration par voie sous- cutan{\'e}e du nickel associe avec le zinc et le s{\'e}l{\'e}nium sur les param{\`e}tres h{\'e}matologique et r{\'e}naux chez les rat Wistar},
	journal = { V{\`e}me Congr{\`e}s International de Biotechnologie et Valorisation des Bio Ressources.22-25 Mars },
	year = {2017},
	address = { TABERKA ,TUNISIE },
	author = {Salah Imane and Ounassa Adjroud}
}
@proceedings {6267,
	title = {Selenium Administration Can Alter Some Biochemical Parameters in Rats},
	journal = {Conference on Healthcare \& Life-Science Research (ICHLSR), 28-29 July 2017},
	year = {2017},
	address = {Barcelona, SPAIN},
	author = {Ounassa Adjroud}
}
@proceedings {7690,
	title = {Effet de l\&rsquo;administration de chlorure de nickel associe avec le selenium sur les param{\`e}tres hematologiques et la glande surr{\'e}nale chez le rat wistar},
	journal = {les 14{\`e}me journ{\'e}es nationales du d{\'e}partement de pharmacie :les m{\'e}thodes d{\textquoteright}analyse de l{\textquoteright}industrie pharmaceutique et en milieu Hospitalier.26,27/04/},
	year = {2016},
	address = {Batna, Alg{\'e}rie},
	author = {Asma Saouli and Ounassa Adjroud and Boulila, Ismah{\`e}ne and Salah, imene and Anfal Fedala}
}
@proceedings {65665,
	title = {Hexavalent Chromium-induced Changes in Biochemical Parameters of Wistar Albino Rats},
	journal = {International Conference on Biological and Chemical Processes (ICBCP), 25-26 April},
	year = {2016},
	month = {2016},
	address = {PARIS, FRANCE},
	abstract = {Potassium dichromate (K2Cr2O7) is one of the most toxic elements to which man can be exposed at work or in the environment. The purpose of the current work is to compare the effect of K2Cr2O7 using variations in the dose, route of administration and duration of exposure in male and female Wistar albino rats with a special focus on biochemical parameters. K2Cr2O7 was subcutaneously administered alone (10, 50 and 100 mg/kg body weight) to female Wistar albino rats. Male rats received in their drinking water K2Cr2O7 30 mg/L/day) for 20 consecutive days. The Biochemical parameters were evaluated on days 3, 6 and 21 after subcutaneous (sc.) treatment in female rats and on days 10 and 20 after oral administration in male rats. The subcutaneous (s.c.) administration of 25 mg/kg of K2Cr2O7 to Wistar albino rats induced a slight change in plasma glucose levels during the experiment period. On the contrary, a significant decrease in plasma glucose levels was observed with 50 mg/kg mainly on days 3 (-26\%) and 21 (-48\%) after treatment compared to controls females rats. On the other hand, the higher dose provoked a significant increase in plasma glucose concentrations on days 6 (+31\%) and 21 (+60\%). similarly, the lower dose of chromium had no effect on the plasma urea levels. Conversely, a significant increase (122\%) in this parameter was obtained during the first three days after treatment. In addition, a significant decrease in plasma glucose levels was observed with 50 mg/kg mainly on days 3 (-26\%) and 21 (-48\%) after treatment. On the other hand, the higher dose provoked a significant increase in plasma glucose concentrations on days 6 (+31\%) and 21 (+60\%). similarly, the lower dose of chromium had no effect on the plasma urea levels. Conversely, a significant increase in this parameter (122\%) was obtained during the first three days after treatment. In addition, administration of 100 mg/kg of K2Cr2O7 by s.c markedly augmented the levels of plasma urea on days 3 (62\%) and 6 (121\%). Administration of 30 mg/L/day of K2Cr2O7 in the drinking water induced a significant augmentation in both of plasma glucose (27\%) and urea (126\%) during the first ten days of treatment. These results suggested that K2Cr2O7 administered subcutaneously or in the drinking water may induce harmful effects on biochemical parameters. Keywords : glucose, potassium dichromate, Wistar albino rat, urea.},
	author = {Ounassa Adjroud}
}
@proceedings {65422,
	title = {Effets de l\&$\#$39;administration par voie sous- cutan{\'e}e du nickel associe avec le zinc et le selenium sur l\&$\#$39;uremie et le determinisme de la reproduction chez les rates gestantes},
	journal = {Premier colloque International de Toxicologie et Sant{\'e}. 28-29 novembre},
	year = {2016},
	month = {2016},
	address = {GUELMA, ALGERIE},
	author = {Imane Salah and Ounassa Adjroud and Ismahene BOULILA and Anfal Fedala and Asma Saouli}
}
@proceedings {6289,
	title = {Contribution {\`a} la recherche des effets du nickel administr{\'e} par voie sous-cutan{\'e}e et son {\'e}ventuelle interaction avec le s{\'e}l{\'e}nium et le zinc sur la leucopo{\"\i}{\`e}se et l\&rsquo;histologie h{\'e}patique},
	journal = {Les 14 {\`e}mes journ{\'e}e nationales de d{\'e}partement de pharmacie {\textendash}.les m{\'e}thodes d{\textquoteright}analyse en milieu hospitalier,{\'e}tat des lieux et perspectives d{\textquoteright}avenir,  27 _28 Avril },
	year = {2016},
	address = {Batna, Alg{\'e}rie},
	author = {Anfal Fedala and Ounassa Adjroud and Salah, Im{\`e}ne and Asma Saouli and Boulila, Ismah{\`e}ne}
}
@proceedings {6268,
	title = {Hexavalent Chromium-induced Changes in Biochemical Parameters of Wistar Albino Rats},
	journal = {Engineering for Life Sciences and Biomedicine" April 25-26,  2016},
	year = {2016},
	address = { PARIS, FRANCE},
	author = {Ounassa Adjroud}
}
@proceedings {6269,
	title = {Interaction between NiCl2 and Selenium on Energy Profiles in Wistar albino Preimplanted Rats},
	journal = { International Conference on Biological and Life Sciences. ~April ~13-15},
	year = {2015},
	address = { Venice, ITALY},
	author = {Ounassa Adjroud}
}
@proceedings {6266,
	title = {Nephroprotective Effects of Selenium against Nickel Chloride-Induced Nephrotoxicity in Pregnant Rats},
	journal = {5th International Conference on Environment Science and Engineering },
	year = {2015},
	author = {Ounassa Adjroud}
}
@proceedings {7692,
	title = {Effet d\&rsquo;administration du chlorure de nickel associ{\'e} avec le s{\'e}l{\'e}nium sur les param{\`e}tres h{\'e}matologiques et la glande surr{\'e}nale chez le rat wistar },
	journal = {XII{\`e}me Journ{\'e}es de Pharmacie et VII{\`e}me Journ{\'e}es de la Douleur 04 et 05 Juin },
	year = {2014},
	address = {Batna, Alg{\'e}rie},
	author = {BOULIA ISMAHENE and Ounassa Adjroud}
}
@proceedings {6271,
	title = {Influence de la vapeur de gazoline sur la modulation de certaines proteines pulmonaires chez le rat blanc.},
	journal = {First International Congress of Biotoxicologie and Bioactivity, 26 and 27 November},
	year = {2014},
	address = {University of Oran 1, Algeria, },
	author = {Ounassa Adjroud}
}
@proceedings {6270,
	title = {Nephroprotective Effects of Selenium against Nickel Chloride-Induced Nephrotoxicity in Pregnant Rats},
	journal = {ICNSE 2014: April 4-5, },
	year = {2014},
	address = {Dubai, UAE},
	author = {Ounassa Adjroud}
}
@article {6262,
	title = {The toxic effects of nickel chloride on liver, erythropoiesis, and development in Wistar albino preimplanted rats can be reversed with selenium pretreatment},
	journal = {Environmental toxicology},
	volume = {28},
	number = {5},
	year = {2013},
	pages = {290-298},
	abstract = {
	The exposure to nickel chloride (NiCl2) can cause hematotoxicity and hepatotoxicity and canaffect development. The present study pertains to the protective effect of selenium (Se) against NiCl2-induced toxicity in preimplanted\&nbsp;Wistar albino\&nbsp;rats. The subcutaneous (s.c.) administration of 25 or 50 mg/kg of NiCl2\&nbsp;to\&nbsp;Wistar albino\&nbsp;rats on day 3 of gestation induced an immediate and significant decrease in maternal body weight and anemia 2 days after treatment. In addition, an increase in plasma aspartate aminotransferase (AST) was observed. These effects were maintained on day 20 of gestation. Moreover, a significant increase in plasma alanine aminotransferase (ALT) levels was observed with the administration of 25 mg/kg of NiCl2. Conversely, administration of 50 mg/kg of NiCl2\&nbsp;by s.c. injection increased erythropoiesis at day 20 of gestation and decreased platelets counts. In addition, administration of 100 mg/kg of NiCl2\&nbsp;markedly reduced the maternal body weight and number of live fetuses and increased fetal loss, predominantly at the end of the experimental period. All dose levels of NiCl2\&nbsp;caused an alteration in the hepatic histoarchitecture. When 0.3-mg/kg Se was injected s.c. with 100-mg/kg NiCl2, the levels of plasma AST and ALT and the structure of the liver were restored. Administration of 20 mg/L/day of NiCl2\&nbsp;in the drinking water significantly reduced the maternal body weight at day five of gestation as well as erythropoiesis during the exposure period. The present study suggests that Se can counteract the nocuous effect of nickel on the liver; however this antioxidant did not prevent alterations in development and erythropoiesis. {\textcopyright} 2011 Wiley Periodicals, Inc. Environ Toxicol 2013.

},
	author = {Ounassa Adjroud}
}
@proceedings {7669,
	title = {Antagonistic Role of Selenium against Hepatotoxic Effects of Nicl2 in Preimplanted Wistar Albino Rats},
	journal = {Sixth International Conference on Environmental Mutagens in Human Populations, Mars},
	year = {2012},
	abstract = {
	Nickel, a potent toxic metal, is very harmful to the environment and to humans because of its in vivo accumulation in liver. The present study was conducted to investigate the protective effect of selenium (Se) against nickel toxicity on liver function in preimplanted Wistar albino rats. NiCl2 was given on day three of pregnancy either in distilled drinking water at a dose of 20 mg/L/day) for 16 consecutive days or as a single s.c. dose of 25, 50, or 100 mg/kg. Se was given as an s.c. injection (0.3 mg/kg) together with the higher dose (100 mg/kg) of NiCl2. Changes in plasma glucose, triglycerides and total cholesterol were measured in treated and control groups on days five and 20 of gestation. NiCl2 s.c. induced on day five of gestation showed a significant (\&lt;0.05) decrease in plasma triglycerides, with a dose of 100 mg / kg (-48 percent). This decrease was maintained at day 20 of gestation with doses of 50 mg / kg (-36 percent) and 100 mg / kg (-31 percent). In contrast, the low dose induced an increase of + 50 percent in plasma triglyceride compared to controls. In addition, NiCl2 s.c. caused on day five of gestation a significant decrease (p \&lt;0.05) in plasma total cholesterol with the low (-50 percent) and medium doses (-26 percent). However, the dose of 100 mg / kg induced a significant increase (114 percent) in plasma total cholesterol on day 20 of gestation compared to controls. NiCl2 s.c. induced a significant increase in plasma glucose (+125 percent) on day 20 of pregnancy. The pretreatment with Se counteracted the effects of NiCl2 on plasma glucose, total cholesterol and triglycerides.



	NiCl2 administered in the drinking water induced a significant increase (\&lt;0.05) in plasma triglycerides (+68 percent) and cholesterol (+49 percent) on day 20 of gestation, while on day five of gestation NiCl2 s.c. induced a significant decrease in cholesterol (-31 percent) compared to controls. All doses of NiCl2 induced an alteration of liver architecture. Co-administration of Se with NiCl2 restored the structure of the liver.



	These results suggested that selenium has a hepatoprotective role against the toxicity induced by NiCl2 administered subcutaneously in preimplanted rats.\&nbsp;

},
	url = {https://www.qscience.com/content/papers/10.5339/qproc.2012.mutagens.3.88},
	author = {Ounassa Adjroud}
}
@proceedings {7671,
	title = {Effects of nickel chloride on reproduction, biochemical parameters in wistar albino rats and possible antagonistic role of selenium},
	journal = {WASET 2011 : World Academy of Science, Engineering and Technology, January 25-27},
	year = {2011},
	address = {Dubai, UAE},
	author = {Mouffouk, Samia and Ounassa Adjroud}
}
@proceedings {7670,
	title = {Protective Effects of Selenium against Nickel Chloride-Induced Neprotoxicity in Preimplanted Rats},
	journal = {e 6th Annual International Symposium on Environment, 16-19 May },
	year = {2011},
	address = {Athens, Greece},
	abstract = {
	The environmental exposure to nickel may have a disastrous impact on human and animal public health. In this study we evaluated the protective effects of selenium against the nephrotoxic effects of NiCl2 in the preimplanted rats. NiCl2 was given on day 3 of pregnancy either as a single subcutaneous (sc) dose of 25, 50 or 100 mg/kg or in distilled drinking water at a dose of 20 mg/L/day for 16 consecutive days. Selenium was given as a sc injection (0.3 mg/kg) together with the higher dose (100 mg/kg) of NiCl2. Changes in plasma creatinine and urea were measured in treated and control groups on days 5 and 20 of gestation. The results showed that 100 mg / kg NiCl2 sc induced a significant increase in plasma creatinine on day 5 of gestation compared with controls. In contrast, on day 20 of gestation the NiCl2 induced a significant decrease in creatinine induced by doses of 25 and 50 mg / kg, whereas dose of 100 mg / kg increased plasma creatinine. Coadministration of selenium with NiCl2 significantly improved plasma creatinine on 5 and 20 days of gestation compared with NiCl2 administered alone. Moreover, on day 5 of gestation the NiCl2 increased significantly plasma concentrations of urea with the low and medium doses which became very significant with the highest dose. On day 20 of gestation, 50 mg / kg NiCl2 induced a significant decrease in plasma urea while the dose of 100 mg / kg induced an increase. Coadministration of selenium did not improve the concentrations of urea induced by NiCl2 alone. The NiCl2 administered in drinking water had no effect on plasma creatinine and urea. 3 doses of NiCl2 (sc) induced an alteration of renal architecture which is markedly improved by Selenium. The NiCl2 taken orally affects the medulla. These results suggested that selenium had no effect against nephrotoxicity induced by NiCl2 administered subcutaneously in pregnant rats.

},
	url = {https://www.atiner.gr/abstracts/2011ENV-ABST.pdf},
	author = {Ounassa Adjroud}
}
@proceedings {7672,
	title = {R{\^o}le antagoniste du S{\'e}l{\'e}nium des effets h{\'e}patotoxiques induits par le Nicl2 chez la rate Wistar pr{\'e}implant{\'e}e},
	journal = {3e congr{\`e}s de toxicologie.11-13 Novembre },
	year = {2010},
	address = { FEZ, MAROC},
	author = {Ounassa Adjroud}
}
@article {7655,
	title = {Protective effects of selenium against potassium dichromate-induced hematotoxicity in female and male Wistar albino rats},
	journal = {Annales de Toxicologie Analytique},
	volume = {22},
	number = {4},
	year = {2010},
	pages = {165-172},
	abstract = {
	Objective:\&nbsp;Potassium dichromate (K2Cr2O7) is a potent pollutant for human and animal health. The purpose of the current work is to compare the effect of K2Cr2O7\&nbsp;using variations in the dose, route of administration and duration of exposure in male and female Wistar albino rats and to research the interaction of chromium and selenium with a special focus on hematopoiesis.\&nbsp;



	Materials and methods:\&nbsp;K2Cr2O7\&nbsp;was subcutaneously administered alone (10, 50 and 100 mg/kg body weight) or K2Cr2O7\&nbsp;(10 mg/kg) in association with selenium (0.3 mg/kg) was administered to female Wistar albino rats. Male rats received in their drinking water K2Cr2O7\&nbsp;(30 mg/L/day) alone or in association with Se (0.3 mg/L/day) for 20 consecutive days. The hematological parameters were evaluated on days 3, 6 and 21 after subcutaneous (sc.) treatment in female rats and on days 10 and 20 after oral administration in male rats.\&nbsp;



	Results:\&nbsp;K2Cr2O7-\&nbsp;induced during the first three days a significant (p\&nbsp;\&lt;\&nbsp;0.05) dose-dependent decrease in the number of erythrocytes, platelets, leucocytes, lymphocytes and the hematocrit levels, and a dose-dependent increase in the number of granulocytes and monocytes. In the drinking water, chromium sc. significantly decreased the number of leucocytes and lymphocytes on day 10 after treatment and elevated the number of granulocytes and monocytes 20 days later. Selenium sc. counterbalanced the hematotoxic effects of chromium in female rats.\&nbsp;



	Conclusion:\&nbsp;These results suggest that the selenium has a protective role against the hematotoxicity of subcutaneous chromium in female Wistar rats.

},
	url = {https://www.ata-journal.org/articles/ata/abs/2010/04/ata100027/ata100027.html},
	author = {Ounassa Adjroud}
}
@proceedings {7693,
	title = {Effet toxique du chlorure de Nickel sur les param{\`e}tres de d{\'e}veloppement chez la rate gestante de souche Wistar},
	journal = {2{\`e}mes  Journ{\'e}es Nationales sur l{\textquoteright}Environnement \& les Conditions de Travail.  27 Avril 2009  Universit{\'e} El Hadj Lakhdar },
	year = {2009},
	address = {Batna, Alg{\'e}rie},
	author = {Ounassa Adjroud and Mouffouk, Samia}
}
@article {7657,
	title = {Effects of potassium dichromate on haematological. parameters in female and male Wistar albino RATS},
	journal = {Ass. Univ. Bull. Environ. Res},
	volume = {12},
	number = {2},
	year = {2009},
	pages = {87-98},
	abstract = {
	Hexavalent chromium is a potent toxic agent. It has been found to be carcinogenic in human and animal. The purpose of the current work is to compare the effect of potassium dichromate (K2Cr2O7) using variations in the dose, route of administration, and duration of exposure in male and female\&nbsp;wistar albino\&nbsp;rats with special focus on hematological parameters. K2Cr2O7\&nbsp;was administered either in the drinking water with a dose of 30 mg/l for 20 consecutive days to male\&nbsp;wistar albino\&nbsp;rats, or as a single dose subcutaneously (s.c) at 10, 50 and 100 mg/Kg body weight (b w) to female\&nbsp;wistar albino\&nbsp;rats. Control groups received NaCl 0.9\% (0.3 ml s.c), or drinking distilled water. Haematological parameters were recorded on day 3, 6, and 21 after subcutaneous exposure, or on day 10 and 20 after oral treatment. 10 mg/Kg b w of K2Cr2O7\&nbsp;given subcutaneously induced during the first three days a marked decrease in the number of erythrocytes (-6\%) of leucocytes (-30\%) of platelets (-48\%) and of hematocrit values (-15\%), while the number of granulocytes is augmented (+124\%) in comparison with control. Hemoglobin concentration and lymphocyte counts decreased markedly on day 6 after exposure. Chromium 50 mg/Kg b w, s.c mainly affected during the first three days the leucopoietic indices inducing leucopoenia (-55\%), lymphopoenia(-57\%), monocytosis (+104\%), granulocytosis (+204\%), and thrombocytosis (+38\%) if compared with control, while the erythrocytic counts and hemoglobin concentration decreased from day 6 (-22\%) and (-21\%) respectively until day 21 (-41\%) and (-36\%) respectively, and hematocrit values decreased at the end of experiment (-36\%) in comparison with control. The higher dose of chromium (100 mg/Kg b w, s.c) reduced during the first three days the number of erythrocytes (-20\%), platelets (-20\%), total leucocytes (-55\%), lymphocytes (-59\%) and augmented the number of monocytes (+56 \%), and granulocytes (+166\%), while on day 6 the number of platelets augmented (+27\%) in comparison with control. In drinking water, 30 mg/l of chromium given to male\&nbsp;wistar albino\&nbsp;rats had no effect on all erythropoietic parameters studied with the exception of the elevation (+21\%) in platelet counts at the end of exposure, while the number of lymphocytes and total leucocytes were significantly reduced on day 20 after exposure (-37\%) and (-37\%) respectively. Conversely, the number of granulocytes and monocytes markedly increased on day 10 after exposure (+42\%) and (+22\%) respectively if compared with control. Short-term exposures to low dose of K2Cr2O7,\&nbsp;s.c induce in female\&nbsp;wistar albino\&nbsp;rats erythrocytopenia, thrombocytopenia, leucopoenia, lymphopaenia, granulocytosis, monocytosis, and a decrease in hematocrit values and hemoglobin concentration while in drinking water chromium was susceptible to affect in male rats the immune response inducing leucopoenia, lymphopoenia, monocytosis, and granulocytosis, while this oral route of exposure had no effect on erythropoietic parameters.

},
	url = {https://auber.journals.ekb.eg/article_149553.html},
	author = {Ounassa Adjroud}
}
@article {7656,
	title = {EFFECTS OF NICKEL CHLORIDE ON HEMATOLOGICAL AND DEVELOPMENTAL PARAMETERS IN Wistar albino PREGNANT RATS},
	journal = {Ass. Univ. Bull. Environ. Res},
	volume = {12},
	number = {1},
	year = {2009},
	abstract = {
	Several reports have suggested that soluble salts nickel may affect on hematopoiesis and development. In this study female Wistar albino rats (180-300g) received NiCl2, 6H2 O, subcutaneously (25, 50 and 100 mg/kg body weight (b w) or in drinking water (20 mg/100 ml). Selenium (0.3 mg/kg b w, s.c.) was combined to NiCl2 (100 mg/kg b w, s.c.). Control groups received NaCl 0.9\% (0.3 ml s.c) or drinking distilled water. All groups of rats were injected on day 4 of pregnancy in pre-implantation period. Haematological parameters were recorded on day 6 and 21 of pregnancy. Developmental parameters were assessed on day 21 of pregnancy. 25 mg/kg b w, of NiCl2 s.c, induced on day 6 an immediate and significant decrease in erythrocyte counts, hematocrit values, and haemoglobin concentrations. This depletion was maintained on day 21 of pregnancy compared to control values.On other hand 50 mg/k b w, NiCl2, s.c, reduced on day 6 of pregnancy the erythrocyte counts, hematocrit values and platelets counts. Inversely, on day 21 this dose elevated the erythrocyte counts, hematocrit values and haemoglobin concentrations ,with depletion of the platelets counts compared to control values. In group introduced 100 mg/kg b w, of NiCl2, s.c had no effect on all haematological parameters studied. NiCl2, significantly reduced the maternal body weight on day 6 and 21 of pregnancy in a dose {\textendash} dependent manner in rats treated subcutaneously and in drinking water compared with control values. NiCl2, s.c. (100 mg/kg b w) markedly reduced the number of live fetuses and elevated the number of abortions on day 21 of pregnancy compared to control values. NiCl2, s.c or in drinking water had no effect on fetal body weight. Selenium (0.3 mg/kg b w, s.c.) combined to NiCl2 (100 mg/kg b w, s.c.) did not improve the effect of NiCl2.

},
	url = {https://auber.journals.ekb.eg/article_149529_d112dce41b27406abc3e4b53dc510831.pdf},
	author = {Ounassa Adjroud and MOUFFOK, S}
}
@proceedings {7675,
	title = {Effets du k2cr2o7 administr{\'e} {\`a} diff{\'e}rentes doses et voies d\&rsquo;administration sur l\&rsquo;{\'e}rythropo{\"\i}{\`e}se chez les rats males et femelles de la souche Wistar},
	journal = {1e  S{\'e}minaire International sur la Valorisation des Ressources Naturelles des Zones semi - Arides , 3- 4 Novembre },
	year = {2008},
	address = {Oum El-Bouaghi, Alg{\'e}rie},
	author = {Ounassa Adjroud}
}
@proceedings {7674,
	title = {Effets du k2cr2o7 administre {\`a} diff{\'e}rentes doses et voies d\&rsquo;administration sur la leucopo{\"\i}{\`e}se chez les rats males et femelles de la souche wistar},
	journal = {2{\`e}mes  Journ{\'e}es Internationales de Toxicologie. Soci{\'e}t{\'e} Alg{\'e}rienne de Toxicologie. 03 - 04 D{\'e}cembre},
	year = {2008},
	address = {Alger, Alg{\'e}rie},
	author = {Ounassa Adjroud}
}
@proceedings {7673,
	title = {Effet toxique du chlorure de Nickel sur la leucopo{\"\i}{\`e}se et les param{\`e}tres de d{\'e}veloppement chez la rate gestante de souche Wistar},
	journal = {2{\`e}mes~ Journ{\'e}es Internationales de Toxicologie. Soci{\'e}t{\'e} Alg{\'e}rienne de Toxicologie. 03 - 04 D{\'e}cembre },
	year = {2008},
	address = {Alger, Alg{\'e}rie},
	author = {Ounassa Adjroud and Mouffouk, Samia}
}
@proceedings {7694,
	title = {Effet de l\&$\#$39;ac{\'e}tate de plomb sur les param{\`e}tres h{\'e}matologiques, la glyc{\'e}mie et le poids chez les rats wistar m{\^a}les et femelles},
	journal = {2{\`e}me Journ{\'e}es Nationales sur la biodiversit{\'e} et l{\textquoteright}environnement naturel et la qualit{\'e} de vie dans la r{\'e}gion des Aur{\`e}s. 27-29 mai 2007 Universit{\'e}  El Hadj Lakhdar BATNA},
	year = {2007},
	address = {Batna, Alg{\'e}rie},
	author = {Mouffouk, Samia and Ounassa Adjroud and BENSMINA}
}
@proceedings {7677,
	title = {Effets des diff{\'e}rentes doses et des diff{\'e}rentes voies d\&$\#$39;administrations de l\&$\#$39;ac{\'e}tate de Plombs  sur les param{\`e}tres h{\'e}matologiques, les concentrations plasmatiques en Glucose et le poids chez les rats Wistar m{\^a}les et fe},
	journal = {The Fourth Scientific Conferences on the Environment \& Natural.  14-16 May },
	year = {2007},
	address = {Taiz University YEMEN},
	author = {Ounassa Adjroud and Mouffouk, Samia}
}
@proceedings {7676,
	title = {Effets des diff{\'e}rentes doses et des diff{\'e}rentes voies d\&$\#$39;administrations de CdCl2 s  sur les param{\`e}tres h{\'e}matologiques, les concentrations plasmatiques en Glucose et le poids chez les rats Wistar m{\^a}les et femelles},
	journal = {The Fourth Scientific Conferences on the Environment \& Natural. 14-16 May },
	year = {2007},
	address = { Taiz University YEMEN},
	author = {Ounassa Adjroud and Mouffouk, Samia}
}
@proceedings {7680,
	title = {Interaction des enk{\'e}phalines avec l\&rsquo;{\OE}stradiol 17beta et la progest{\'e}rone placentaires et ut{\'e}rines chez la rate pr{\'e} parturiente},
	journal = {2e Colloque Eurom{\'e}diterran{\'e}en de Biologie Environnementale , 07 -10 D{\'e}cembre },
	year = {2006},
	author = {Ounassa Adjroud}
}
@proceedings {7679,
	title = {Interaction des enk{\'e}phalines avec l\&rsquo;{\OE}stradiol 17beta et la progest{\'e}rone placentaires et ut{\'e}rines chez la rate pr{\'e} parturiente},
	journal = {2e Colloque Eurom{\'e}diterran{\'e}en de Biologie Environnementale , 07 -10 D{\'e}cembre },
	year = {2006},
	address = {Marseille, FRANCE},
	author = {Ounassa Adjroud and Clabaut ,M}
}
@proceedings {7678,
	title = {Interaction des enk{\'e}phalines avec les prostaglandines F2 alpha et E2 placentaires et ut{\'e}rines chez la rate pr{\'e} parturiente},
	journal = {2e Colloque Eurom{\'e}diterran{\'e}en de Biologie Environnementale  07 -10 D{\'e}cembre},
	year = {2006},
	address = {Marseille, France},
	author = {Ounassa Adjroud}
}
@proceedings {7681,
	title = {Interaction de la TSH , T3 et T4  avec les gonadotrophines FSH et LH chez la femme pr{\'e}- m{\'e}nopaus{\'e}e},
	journal = {1er S{\'e}minaire International de Biologie et Physiologie de la Reproduction, 6-7 D{\'e}cembre },
	year = {2005},
	address = {Batna, Alg{\'e}rie},
	author = {Ounassa Adjroud and Allaoui, N and Benour, T}
}
@proceedings {7695,
	title = {La douleur et la morphinoth{\'e}rapie},
	journal = {Journ{\'e}es de concertation pour la finalisation du programme national de Recherche en Sant{\'e}. 26-27 F{\'e}vrier },
	year = {1997},
	address = {Alger, Alg{\'e}rie},
	author = {Ounassa Adjroud}
}
@article {7660,
	title = {Les opiac{\'e}s endog{\`e}nes et la motricit{\'e} ut{\'e}rine pendant la gestation},
	journal = {Journal Alg{\'e}rien de M{\'e}decine },
	volume = {VII},
	number = {4},
	year = {1997},
	pages = {128-133},
	author = {Ounassa Adjroud}
}
@article {7659,
	title = {Action Of Naloxone And Acetorphan, On Uterine Contractions Induced By Oxytocin -in Periparturient Rat In Vivo},
	journal = {Synth{\`e}se},
	volume = {3},
	number = {1},
	year = {1997},
	pages = {63-68},
	abstract = {
	Theffects{\textquoteright} in vivo of acetorphan, an _enkephalinase inhibitor and naloxone, an opiate antagonist on the - - oxytocin- induced myometrial mechanical activity were studied at day 21 of pregnancy in rats. Acetarpban" I 10 mg kg -1 (i.v.) increased (344\%) spontaneous uterine contractions duration only at 0-10 min period, but - did not modify amplitude. This increase in the duration was blocked by naloxone 5 mg ks -1, which had no effect on the amplitude or duration of contractions when given alone. Oxytocin (~T), I, 10 and I 100 mIU (i.v.) stimulated in a dose dependent manner, spontaneous uterine contractions duration but did not alter the amplitude of contractions. Blocking the opioid peptides by naloxone, 5 mg kg -1 (s.c.) injected --10min before OT strongly potentiated the effect of the lowest dose of OT (1 mlU) b-yabout of 59\&amp;Ofn and doubled the amplitude of contractions during the 30 min observation period. When acetorphan, 10 mg kg _-1 (i.v.) administered 30 min before the lowest dose of OT studied, 1 mID (i.v.), It induced a slight increase by .about 88\% in uterine contractions duration produced by OT alone, The amplitude remained unchanged. These -results suggested that uterine contractions induced by OT in late pregnancy in rats might be regulated by enkephalinergie and enkephalinasic systems

},
	url = {https://www.asjp.cerist.dz/en/article/78944},
	author = {Ounassa Adjroud}
}
@article {6263,
	title = {Peripheral excitatory effects of two enkephalinase inhibitors, acetorphan and thiorphan, and an enkephalin analogue, [d-Ala2\&ndash;Met5]-enkephalinamide, on uterine motility in periparturient rats in vivo and in vitro},
	journal = {Journal for Reproduction and Fertility},
	volume = {104},
	number = {2},
	year = {1995},
	pages = {181{\textendash}186 },
	abstract = {
	The effects of two enkephalinase inhibitors, acetorphan and thiorphan, and the enkephalin analogue [d-Ala2\p=n-\Met5]-enkephalinamide (DAMEA), on spontaneous uterine contractions were studied at day 21 of pregnancy in rats following treatment in vivo or in vitro. Acetorphan (10 mg kg\m=-\1)and thiorphan (1 mg kg\m=-\1),immediately after their i.v. administration, increased the duration of spontaneous contractions 3.4- and 4.6-fold, respectively, but did not modify the maximum amplitude. Similarly, thiorphan (40 \g=m\moll\m=-\1) increased the duration of contractions when administered in vitro. Thiorphan was ineffective during the first 30 min when given into the cerebral ventricles (50 \g=m\gper rat). These results suggest that the enkephalinase inhibitors are acting via a peripheral opioid pathway; and this conclusion is supported by the observation that thiorphan potentiated the stimulatory effect of a submaximal dose of DAMEA administered in vitro. The excitatory effects of DAMEA and the enkephalinase inhibitors were blocked by naloxone. This antagonistic effect of naloxone on uterine motility in the periparturient rat uterus, induced by either acetorphan and thiorphan or DAMEA, seems to be regulated by peripheral opiate receptors. Naloxone (10 mg kg\m=-\1 s.c.) increased both the amplitude and duration of uterine motility in vivo; however, naloxone (26 \g=m\moll\m=-\1 and 52 \g=m\moll\m=-\1) produced a paradoxical dose-dependent biphasic effect in vitro.

},
	url = {https://rep.bioscientifica.com/view/journals/rep/104/2/jrf_104_2_001.xml},
	author = {Ounassa Adjroud}
}
@proceedings {7696,
	title = {Effets stimulateurs de deux inhibiteurs de l\&rsquo;enkephalinase sur la motilit{\'e} ut{\'e}rine chez la rate pr{\'e}parturiente},
	journal = {Journ{\'e}e Scientifique V{\'e}t{\'e}rinaire. 22 Mai 1989, El Hadj Lakhdar },
	year = {1989},
	address = {Batna, Alg{\'e}rie},
	author = {Ounassa Adjroud}
}
@article {7658,
	title = {Variation of myometrial activities and steroid sexual hormones following bilateral ovariectomy in the rat at midpregnancy},
	journal = {Acta Physiol Hung},
	volume = {71},
	number = {4},
	year = {1988},
	pages = {477-83},
	abstract = {
	The effects of bilateral ovariectomy on uterine motility and levels of progesterone, oestradiol, cAMP, adrenaline and PGF2 alpha were studied in the rat at midpregnancy. Animals were randomly divided into two groups, at least 15 rats in each, sham-operated serving as controls and ovariectomized. The spontaneous uterine mechanical activity of Wistar rats was recorded isometrically and the electrical activities were recorded simultaneously by two bipolar electrodes. Within 30 minutes of ovariectomy a significant increase of the amplitude of uterine contractions was observed and the simultaneity of electrical activity was significantly improved; these effects became more pronounced at 1h post-ovariectomy (p less than 0.005). Plasma progesterone levels decreased by 20\% (p less than 0.01) at 30 min and by 50\% (p less than 0.001) 1h after ovariectomy, whereas oestrogen levels remained unchanged. Levels of adrenaline, cAMP and PGF2 alpha in the uterine tissue 1h following ovariectomy were affected as follows: adrenaline (p less than 0.05) and cAMP (p less than 0.001) were reduced and PGF2 alpha augmented (p less than 0.05). It appears that variation of the ratio oestrogens/progesterone induces precociously the activation of uterine mobility and exerts an effect on some factors involved in the regulation of the rat myometrium at midpregnancy.

},
	url = {https://pubmed.ncbi.nlm.nih.gov/2849861/},
	author = {Clabaut ,M and Duclos,  R and Chartrel, N and Ounassa Adjroud and Acritopoulou-Fourcroy, S and Collado, H and Schrub, J C}
}
