@article {2400,
	title = {Compounds from Sedum caeruleum with antioxidant, anticholinesterase, and antibacterial activities},
	journal = { Pharm. Biol},
	volume = {54},
	number = {1},
	year = {2016},
	pages = {174{\textendash}179},
	abstract = {
	Context: This is the first study on the phytochemistry, antioxidant, anticholinesterase, and antibacterial activities of\&nbsp;Sedum caeruleum\&nbsp;L. (Crassulaceae).



	Objective: The objective of this study is to isolate the secondary metabolites and determine the antioxidant, anticholinesterase, and antibacterial activities of\&nbsp;S. caeruleum.



	Materials and methods: Six compounds (1{\textendash}6) were isolated from the extracts of\&nbsp;S. caeruleum\&nbsp;and elucidated using UV, 1D-, 2D-NMR, and MS techniques. Antioxidant activity was investigated using DPPH{\textbullet}, CUPRAC, and ferrous-ions chelating assays. Anticholinesterase activity was determined against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes using the Ellman method. Antibacterial activity was performed according to disc diffusion and minimum inhibitory concentration (MIC) methods.



	Results: Isolated compounds were elucidated as ursolic acid (1), daucosterol (2), β-sitosterol-3-O-β-d-galactopyranoside (3), apigenin (4), apigetrin (5), and apiin (6). The butanol extract exhibited highest antioxidant activity in all tests (IC50\&nbsp;value: 28.35 {\textpm} 1.22 {\textmu}g/mL in DPPH assay, IC50\&nbsp;value: 40.83 {\textpm} 2.24 {\textmu}g/L in metal chelating activity, and IC50value: 23.52 {\textpm} 0.44 {\textmu}g/L in CUPRAC), and the highest BChE inhibitory activity (IC50\&nbsp;value: 36.89 {\textpm} 0.15 {\textmu}g/L). Moreover, the chloroform extract mildly inhibited (MIC value: 80 {\textmu}g/mL) the growth of all the tested bacterial strains.



	Discussion and conclusion: Ursolic acid (1), daucosterol (2), β-sitosterol-3-O-β-d-galactopyranoside (3), apigenin (4), apigetrin (5), and apiin (6) were isolated from\&nbsp;Sedum caeruleum\&nbsp;for the first time. In addition, a correlation was observed between antioxidant and anticholinesterase activities of bioactive ingredients of this plant.

},
	author = {Chawki Bensouici and Ahmed Kabouche and Anastasia Karioti and Mehmet {\"O}zt{\"u}rk and Mehmet Emin Duru and Anna Rita Bilia and Zahia Kabouche}
}
@article {2397,
	title = {Oleanolic acid and hederagenin glycosides from Weigela stelzneri},
	journal = {Phytochemistry},
	volume = {123},
	year = {2016},
	pages = {40-47},
	abstract = {
	Four previously undescribed and one known oleanolic acid glycosides were isolated from the roots of Weigela stelzneri, and one previously undescribed and three known hederagenin glycosides were isolated from the leaves. Their structures were elucidated mainly by 2D NMR spectroscopic analysis and mass spectrometry as 3-O-β-D-glucopyranosyl-(1 {\textrightarrow} 2)-[β-D-xylopyranosyl-(1 {\textrightarrow} 4)]-β-D-xylopyranosyl-(1 {\textrightarrow} 4)-β-D-xylopyranosyl-(1 {\textrightarrow} 3)-α-L-rhamnopyranosyl-(1 {\textrightarrow} 2)-α-L-arabinopyranosyloleanolic acid, 3-O-β-D-glucopyranosyl-(1 {\textrightarrow} 2)-[β-D-xylopyranosyl-(1 {\textrightarrow} 4)]-β-D-xylopyranosyl-(1 {\textrightarrow} 4)-β-D-xylopyranosyl-(1 {\textrightarrow} 3)-α-L-rhamnopyranosyl-(1 {\textrightarrow} 2)-β-D-xylopyranosyloleanolic acid, 3-O-β-D-glucopyranosyl-(1 {\textrightarrow} 2)-[β-D-glucopyranosyl-(1 {\textrightarrow} 4)]-β-D-xylopyranosyl-(1 {\textrightarrow} 4)-β-D-xylopyranosyl-(1 {\textrightarrow} 3)-α-L-rhamnopyranosyl-(1 {\textrightarrow} 2)-β-D-xylopyranosyloleanolic acid, 3-O-β-D-glucopyranosyl-(1 {\textrightarrow} 2)-[β-D-xylopyranosyl-(1 {\textrightarrow} 4)]-β-D-xylopyranosyl-(1 {\textrightarrow} 4)-β-D-xylopyranosyl-(1 {\textrightarrow} 3)-α-L-rhamnopyranosyl-(1 {\textrightarrow} 2)-α-L-arabinopyranosyloleanolic acid 28-O-β-D-glucopyranosyl-(1 {\textrightarrow} 6)-β-D-glucopyranosyl ester, and 3-O-β-D-glucopyranosyl-(1 {\textrightarrow} 2)-α-L-arabinopyranosylhederagenin 28-O-β-D-xylopyranosyl-(1 {\textrightarrow} 6)-[α-L-rhamnopyranosyl-(1 {\textrightarrow} 2)]-β-D-glucopyranosyl ester. The majority of the isolated compounds were evaluated for their cytotoxicity against two tumor cell lines (SW480 and EMT-6), and for their anti-inflammatory activity. The compounds 3-O-β-D-glucopyranosyl-(1 {\textrightarrow} 2)-[β-D-xylopyranosyl-(1 {\textrightarrow} 4)]-β-D-xylopyranosyl-(1 {\textrightarrow} 4)-β-D-xylopyranosyl-(1 {\textrightarrow} 3)-α-L-rhamnopyranosyl-(1 {\textrightarrow} 2)-α-L-arabinopyranosyloleanolic acid and 3-O-β-D-glucopyranosyl-(1 {\textrightarrow} 2)-[β-D-xylopyranosyl-(1 {\textrightarrow} 4)]-β-D-xylopyranosyl-(1 {\textrightarrow} 4)-β-D-xylopyranosyl-(1 {\textrightarrow} 3)-α-L-rhamnopyranosyl-(1 {\textrightarrow} 2)-β-D-xylopyranosyloleanolic acid exhibited the strongest cytotoxicity on both cancer cell lines. They revealed a 50\% significant inhibitory effect of the IL-1β production by PBMCs stimulated with LPS at a concentration inducing a very low toxicity of 23\% and 28\%, respectively.

},
	author = {A Rezgui and A-C Mitaine-Offer and T Miyamoto and C Tanaka and S Delemasure and P Dutartre and M-A Lacaille-Dubois}
}
@article {1685,
	title = {Antitumor effect of Deoxypodophyllotoxin on human breast cancer xenograft transplanted in BALB/c nude mice model. Khaled M, Belaaloui G, Jiang ZZ, Zhu X, Zhang LY},
	journal = {J Infect Chemother.~2016 Oct;22(10):692-6. doi: 10.1016/j.jiac.2016.07.017. Epub 28 Ao{\^u}t},
	year = {2016},
	author = {Meyada KHALED and Ghania Belaaloui and Zhenzhou Jiang and Xiong Zhu and Luyong Zhang}
}
@article {1600,
	title = {Lack of Association between CYP1A1 M2 and M4 Polymorphisms and Breast Carcinoma in Jordanian Women: a Case-Control Study},
	journal = {Asian Pacific Journal of Cancer Prevention: APJCP 2016},
	volume = {17},
	number = {1},
	year = {2016},
	pages = {387-393},
	author = {Iman Amrani and Nailya Bulatova and Abdalla Awidi and Al-Motassem Yousef and Jamal Masad Melhem and Mahmoud Al-Masri and Laila Abu Tahoun}
}
