<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Khamsa Mokrani</style></author><author><style face="normal" font="default" size="100%">PE Fournier</style></author><author><style face="normal" font="default" size="100%">Mokhtar Dalichaouche</style></author><author><style face="normal" font="default" size="100%">Soraya Tebbal</style></author><author><style face="normal" font="default" size="100%">Ahmed Aouati</style></author><author><style face="normal" font="default" size="100%">Didier Raoult</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Reemerging threat of epidemic typhus in Algeria</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Clinical Microbiology [J Clin Microbiol], ISSN: 0095-1137, PMID: 15297561, Aug </style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2004</style></year></dates><volume><style face="normal" font="default" size="100%">42</style></volume><pages><style face="normal" font="default" size="100%">pp 3898-900</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">We report a case of epidemic typhus in a patient from the Batna region of Algeria, who presented with generalized febrile exanthema. The clinical diagnosis was confirmed by serological cross-adsorption followed by Western blotting. Our report emphasizes the threat of epidemic typhus in the highlands of Algeria.</style></abstract><issue><style face="normal" font="default" size="100%">8</style></issue></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Soraya Tebbal</style></author><author><style face="normal" font="default" size="100%">Veronique Massari</style></author><author><style face="normal" font="default" size="100%">Mahinda Siriwardana</style></author><author><style face="normal" font="default" size="100%">M Grandadam</style></author><author><style face="normal" font="default" size="100%">Ahmed Aouati</style></author><author><style face="normal" font="default" size="100%">Bernard Larouze</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Retrospective study of an epidemic of hepatitis E in a village of the Algerian North-East</style></title></titles><dates><year><style  face="normal" font="default" size="100%">2004</style></year></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marc Grandadam</style></author><author><style face="normal" font="default" size="100%">Soraya Tebbal</style></author><author><style face="normal" font="default" size="100%">Elisabeth Nicand</style></author><author><style face="normal" font="default" size="100%">Mahinda Siriwardana</style></author><author><style face="normal" font="default" size="100%">Pierre Coursaget</style></author><author><style face="normal" font="default" size="100%">Bernard Larouze</style></author><author><style face="normal" font="default" size="100%">S Tsarev</style></author><author><style face="normal" font="default" size="100%">Yves Buisson</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Retrospective molecular analysis of an algerian hepatitis E epidemic </style></title><secondary-title><style face="normal" font="default" size="100%">39th ICAAC</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2004</style></year></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marc Grandadam</style></author><author><style face="normal" font="default" size="100%">Soraya Tebbal</style></author><author><style face="normal" font="default" size="100%">Mélanie Caron</style></author><author><style face="normal" font="default" size="100%">Mahinda Siriwardana</style></author><author><style face="normal" font="default" size="100%">Bernard Larouze</style></author><author><style face="normal" font="default" size="100%">Jean Louis Koeck</style></author><author><style face="normal" font="default" size="100%">Yves Buisson</style></author><author><style face="normal" font="default" size="100%">Vincent Enouf</style></author><author><style face="normal" font="default" size="100%">Elisabeth Nicand</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evidence for hepatitis E virus quasispecies</style></title><secondary-title><style face="normal" font="default" size="100%">Jounal of General Virology </style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2004</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.80248-0</style></url></web-urls></urls><pages><style face="normal" font="default" size="100%">3189-3194</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The genetic diversity of hepatitis E virus (HEV) has been extensively analysed during the last decade. Most sporadic and epidemic HEV strains are distributed into genotypes or groups. Nevertheless, few studies have looked at the polymorphism of HEV strains isolated from a given outbreak. A serum bank collected in Tanefdour, Algeria, during an acute hepatitis epidemic (1986–1987), retrospectively confirmed as hepatitis E, was analysed. Of the 69 serum samples collected within an 8-week period, 23 were positive for both partial ORF1 (replicase gene) and ORF2 (capsid gene) sequences. Inter- and intra-patient diversities were assessed by RFLP, and by sequencing a 448 bp sequence corresponding to ORF2. RFLP analysis distinguished three profiles: A (18/23), B (3/23) and C (2/23). Most isolates (18/23) shared 99·7–100 % sequence identity and the remainder showed 1–1·3 % divergence. HEV intra-patient diversity was studied using 12 isolates (seven displaying the major RFLP profile and five displaying minor RFLP profiles). For 9 of 12 isolates, additional intra-patient heterogeneity was revealed by RFLP analysis of 100 clones from each isolate and sequence diversity ranging from 0·11 to 3·4 %. These data strongly support the quasispecies organization of HEV during epidemics and could explain the adaptable behaviour of the virus in the host–pathogen interrelations.</style></abstract><issue><style face="normal" font="default" size="100%">85</style></issue></record></records></xml>